EV-ER: Nano-Extracellular Vesicles and Organ Dysfunction
The project aims to:
- evaluate the potential of stem cell-derived nEVs to modify the pro-fibrotic phenotype and inhibit the progression of chronic damage in preclinical models of hepatic and renal fibrosis.
- identify the molecular mechanisms involved in cellular reprogramming by studying the gene profile of damaged tissues before and after treatment with nEVs in order to identify the “pathways” involved and modified by the treatment
- develop nEVs engineered with anti-fibrotic molecules for use as a therapy vehicle
- develop large-scale GMP production technology platforms of nEVs, in order to study biodistribution and biosecurity in preclinical models
The project is realized thanks to the co-funding of POR FESR Piemonte 2014-2020 ACTION I.1.b.2.2 e and of POR FSE Piemonte 2014-2020 ACTION 1.8.II.2.3.1 “Piattaforma Salute e Benessere”.